High doses of a substance can produce very different effects from low doses. It is important to note that any substance-whether an illegal drug or something like everyday water-can benefit or harm a person depending upon its quantity and potency (strength). In true market fashion, the price usually goes up during these Dose When the key chemicals needed to make meth are not as readily available and therefore are more costly, purity falls because the cooks need to bolster production by adding other substances to the meth. This reflects a basic supply and demand market. The purity of meth has risen and fallen over the years. It is important to remember that it is never possible to know the exact strength or purity of the meth, even if the meth is obtained from a familiar supplier. Heavy meth users may even prefer these additives because the impurities can give a more intense rush. In 2005, the purity of street meth averaged about 54 percent, and contained such substances as baking soda, Epsom salts, quinine (a malaria drug), mannitol (a sugar alternative), ether (a toxic solvent), insecticides (a poison), monosodium glutamate (a preservative), photo developer (a toxic solvent), and strychnine (a poison). This decreases the purity but increases the total amount of product available to sell. To make more money, powdered meth is diluted, or 'cut,' with other ingredients and chemicals. Small-scale labs produce meth with much lower purity. Depending on the method used, the purity of the meth from superlabs ranges from 80 to 90 percent. Superlabs produce the purest and most potent meth because they have trained chemists making the drug. The more intensely a drug effects someone, the more it potentially addictive it is. The more potent a drug, the more intense are its effects. The purer the drug, the more potent it is. For the smaller labs, an investment of about $1,500 in ingredients can be turned into $15,000 in meth sales, a tenfold increase. A superlab making an average amount of meth-100 pounds-can earn the manufacturer about $4 million when sold on the street. Overall, the price of meth has declined since the 1980s, but for illicit meth manufacturers, it is still a profitable business. The price of meth also depends upon the amount purchased and where in the country it is sold. **Lowest retail prices for one-eighth ounce: Los Angeles, San Diego, and Phoenix *Highest retail prices for one gram: Honolulu, Miami, Detroit, and New York City Notice how an ounce of gold compares with an ounce of meth. Heavy meth users take three or more grams of meth at a time. Because of ice's intensity, smaller doses provide bigger highs a gram of ice can provide 10 to 25 hits (doses) of meth. An average dose of meth is about a quarter of a gram.

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